반응 #529342

ord-ef9e520af5fd47e9aa4246170b1cf50f

반응 방정식

COC(=O)C1=C(C)NC(C)=C(C(=O)OCc2ccc(Cl)cc2)C1c1cccc([N+](=O)[O-])c1
2,6-dimethyl-3-methoxycarbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 4-chlorobenzyl ester
→
C/C(N)=C/C(=O)OCc1ccc(Cl)cc1
β-aminocrotonic acid 4-chlorobenzyl ester
수율 72.0%

반응물

COC(=O)C1=C(C)NC(C)=C(C(=O)OCc2ccc(Cl)cc2)C1c1cccc([N+](=O)[O-])c1
2,6-dimethyl-3-methoxycarbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 4-chlorobenzyl ester

시약

없음

용매

CCO
ethanol
CCO
ethanol

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Analogously to Example 1 heating a solution of 75 mmols of 3'-nitrobenzylideneacetoacetic acid methyl ester and 75 mmols of β-aminocrotonic acid 4-chlorobenzyl ester in 120 ml of ethanol gave 2,6-dimethyl-3-methoxycarbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 4-chlorobenzyl ester of melting point 169° C (from ethanol).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US04044141uspto-grants-1977_08