반응 #529339

ord-6a1974af24f74f40a581502c26282000

반응 방정식

COC(=O)C1=C(C)NC(C)=C(C(=O)OCc2ccc(Cl)c(Cl)c2)C1c1ccccc1[N+](=O)[O-]
2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 3,4-dichlorobenzyl ester
CCO
ethanol
CCCO
n-propanol
→
C/C(N)=C/C(=O)OCc1ccc(Cl)c(Cl)c1
β-aminocrotonic acid 3,4-dichlorobenzyl ester
COC(=O)CC(=O)/C=C/c1ccccc1[N+](=O)[O-]
2'-nitrobenzylideneacetoacetic acid methyl ester

반응물

COC(=O)C1=C(C)NC(C)=C(C(=O)OCc2ccc(Cl)c(Cl)c2)C1c1ccccc1[N+](=O)[O-]
2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 3,4-dichlorobenzyl ester
CCO
ethanol
CCCO
n-propanol

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Analogously to Example 1 heating a solution of 75 mmols of 2'-nitrobenzylideneacetoacetic acid methyl ester and 75 mmols of β-aminocrotonic acid 3,4-dichlorobenzyl ester in 120 ml of n-propanol gave 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 3,4-dichlorobenzyl ester of melting point 137° C (from ethanol).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US04044141uspto-grants-1977_08