반응 #5293
ord-7b87461ecdde45988aceaf88c872f80d
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1여과The mixture is then filtered
- 2농축the filtrate is concentrated under reduced pressure
실험 절차
A solution of 6.5 g of ethyl 2-(4-methylphenyl)-3-nitropropyl(diethoxymethyl)phosphinate in 60 ml of ethanol is added to 52 g of an 8% solution of ammonia in ethanol. To this are added 8 ml of Raney Nickel and the resulting mixture is hydrogenated at 1 bar until the theoretical amount of hydrogen has been taken up. The mixture is then filtered and the filtrate is concentrated under reduced pressure to give ethyl 3-amino-2-(4-methylphenyl)propyl(diethoxymethyl)phosphinate as a viscous oil, 31 p=+44.6 ppm (CDCl3).