반응 #52925

반응 방정식

NaBH4

N-(2,6-dichlorobenzoyl)-4-(2-formylphenyl)-L-phenylalanine methyl ester

→

N-(2,6-dichlorobenzoyl)-4-[2-(hydroxymethyl)phenyl]-L-phenylalanine methyl ester

수율 103.9%

용매

MeOH

반응 조건

후처리

1. 1
   기타The reaction was quenched with acetone
2. 2
   기타the mixture was evaporated
3. 3
   기타The residue was partitioned between EtOAc and water
4. 4
   건조The EtOAc layer was dried (MgSO4)
5. 5
   기타evaporated

실험 절차

NaBH4 (21 mg) was added to a solution of N-(2,6-dichlorobenzoyl)-4-(2-formylphenyl)-L-phenylalanine methyl ester (0.23 g) in MeOH (5 mL) and the mixture was stirred at room temperature for 3 h. The reaction was quenched with acetone and the mixture was evaporated. The residue was partitioned between EtOAc and water. The EtOAc layer was dried (MgSO4) and evaporated to yield N-(2,6-dichlorobenzoyl)-4-[2-(hydroxymethyl)phenyl]-L-phenylalanine methyl ester (0.24 g). ESMS: m/z 480 ([M+Na]+).

출처