반응 #528617

반응 방정식

cyclohexene oxide

dimethylamine

→

2-dimethylamino-1-cyclohexanol

반응 조건

후처리

1. 1
   온도was heated
2. 2
   농축While the mixture was being concentrated to dryness at 50° on a film evaporator, absolute ethanol
3. 3
   workup.ADDITIONwas added periodically
4. 4
   기타to aid in removal of water
5. 5
   workup.DISTILLATIONThe residue was distilled through a Nester-Faust

실험 절차

A mixture of 50.0 g of cyclohexene oxide and 100 ml of 25 percent aqueous dimethylamine was heated with stirring at 145° in a small autoclave for 8 hours. While the mixture was being concentrated to dryness at 50° on a film evaporator, absolute ethanol was added periodically to aid in removal of water. The residue was distilled through a Nester-Faust spinning band column to give 53.0 g of 2-dimethylamino-1-cyclohexanol, b.p. 64.1 - 64.2/2.4 mm. The ir curve was consistent with the assigned structure.

출처