반응 #5279
ord-a5f9fd3310074c17a1faf12c0f5dc92c
반응 방정식
ethyl 3-amino-2-phenylpropyl(diethoxymethyl)phosphinate
→
ethyl 3-amino-2-cyclohexylpropyl(diethoxymethyl)phosphinate
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1여과The mixture is then filtered
- 2농축the filtrate is concentrated under reduced pressure
- 3기타The crude product is chromatographed on silica gel
실험 절차
A solution of 3.45 g of ethyl 3-amino-2-phenylpropyl(diethoxymethyl)phosphinate in 25 ml of tertiary butanol is added to 2.0 g of 5% rhodium in alumina, suspended in 25 ml of tertiary butanol. The resulting mixture is hydrogenated at an atmosphere of 150 bar and temperature of 100° C. for a period of 20 hours. The mixture is then filtered and the filtrate is concentrated under reduced pressure. The crude product is chromatographed on silica gel using ethanol as eluent to give ethyl 3-amino-2-cyclohexylpropyl(diethoxymethyl)phosphinate as a viscous oil, 31P=47.1 and +47.0 ppm (CDCl3).