반응 #527688

반응 방정식

2-bromoethanol

7 -benzyloxy-1-[1-(2 -chlorophenyl)cyclopropyl]-6-methoxy-1,2,3,4-tetrahydroisoquinoline

potassium carbonate

→

7-benzyloxy-1-[1-(2-chlorophenyl)cyclopropyl]-2-(2-hydroxyethyl)-7-methoxy-1,2,3,4-tetrahydroisoquinoline

용매

acetone

반응 조건

후처리

1. 1
   기타prepared in a similar manner to that
2. 2
   온도was heated
3. 3
   온도under reflux for 18 hours
4. 4
   여과The mixture was filtered
5. 5
   세척the solids washed with acetone
6. 6
   기타the filtrate solvent removed in vacuo

실험 절차

A mixture of 7 -benzyloxy-1-[1-(2 -chlorophenyl)cyclopropyl]-6-methoxy-1,2,3,4-tetrahydroisoquinoline (2.83 g, liberated from the hydrobromide salt prepared in a similar manner to that described in Example RC14), acetone (40 ml), anhydrous potassium carbonate (5.5 g) and 2-bromoethanol (3.6 ml) was heated under reflux for 18 hours. The mixture was filtered, the solids washed with acetone, and the filtrate solvent removed in vacuo to give 7-benzyloxy-1-[1-(2-chlorophenyl)cyclopropyl]-2-(2-hydroxyethyl)-7-methoxy-1,2,3,4-tetrahydroisoquinoline as an oil.

출처