반응 #526884

반응 방정식

6-octyloxy-2-naphthoic acid

dicyclohexylcarbodiimide

pentafluorophenol

→

pentafluorphenyl 6-octyloxy-2-naphthoate

수율 110.3%

용매

ethyl acetate

반응 조건

후처리

1. 1
   기타The precipitate was removed by s filtration
2. 2
   세척The filtrate was washed with water (2×150 ml) and brine
3. 3
   건조dried with magnesium sulfate
4. 4
   기타Removal of the ethyl acetate in vacuo

실험 절차

To a suspension of 6-octyloxy-2-naphthoic acid (3.15 g, 10.5 mmol) and dicyclohexylcarbodiimide in ethyl acetate (25 ml) at 0° C. was added pentafluorophenol (2.12 g, 11.5 mmol). The mixture was stirred at 25° C. for a period of 18 h. The precipitate was removed by s filtration. The filtrate was washed with water (2×150 ml) and brine and dried with magnesium sulfate. Removal of the ethyl acetate in vacuo gave 5.4 g of pentafluorphenyl 6-octyloxy-2-naphthoate as a solid: 1H NMR (400 MHz, CH3OD) δ 0.88 (t, 3, J=6.9 Hz), 4.10 (t, 2, J=6.6 Hz), 7.16 (d, 1), 7.21 (d, 1), 7.80 (d, 1), 7.87 (d,1), 8.08 (dd, 1), 8.69 (d, 1).

출처