반응 #526677

반응 방정식

2-acetamido-5-fluoro-3-nitrobenzotrifluoride

→

2-amino-5-fluoro-3-nitrobenzotrifluoride

수율 50.0%

용매

HCl

반응 조건

후처리

1. 1
   온도was refluxed overnight
2. 2
   추출it was extracted by ethyl acetate (2×10 mL)
3. 3
   건조The extract was dried over Mg2SO4
4. 4
   기타evaporated

실험 절차

A mixture of 2-acetamido-5-fluoro-3-nitrobenzotrifluoride (1.50 g, 5.64 mmol) in concentrated HCl (10 mL) was refluxed overnight and it was extracted by ethyl acetate (2×10 mL). The extract was dried over Mg2SO4, and evaporated to give 624 mg of 2-amino-5-fluoro-3-nitrobenzotrifluoride (50%). 1H NMR (CDCl3): δ6.547 (s, 2H), 7.570 (dd, 1H, J1 =2.7 Hz, J2 =5.7 Hz), 8.114 (dd, 1 H, J1 =2.7 Hz, J2 =5.7 Hz).

출처