반응 #52615

반응 방정식

5-aminolevulinic acid hydrochloride

1,3-cyclohexanedione

sodium acetate

→

3-(4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)-propionic acid

수율 82.0%

용매

water

반응 조건

후처리

1. 1
   온도cooled
2. 2
   기타The precipitate which formed
3. 3
   여과was collected by vacuum filtration
4. 4
   세척washed with 30% of ethanol in water
5. 5
   기타dried under vacuum

실험 절차

A mixture of 5-aminolevulinic acid hydrochloride (1.68 g, 10 mmol), 1,3-cyclohexanedione (1.12 g, 10 mmol) and sodium acetate (1.64 g, 20 mmol) in water (10 mL) was stirred at 110° C. for 4 hr and then cooled. The precipitate which formed was collected by vacuum filtration, washed with 30% of ethanol in water and dried under vacuum to give 1.7 g (82%) of 3-(4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)-propionic acid.

출처