반응 #52497

반응 방정식

ethyl 4-[4-(1-benzylamino-cyclopropyl)-phenylethynyl]-benzoate

Compound 111

ethyl 4-[4-(1-benzylamino-cyclopropyl)-phenylethynyl]-benzoate

NaOH

→

title compound

수율 50.1%

4-[4-(1-Benzylamino-cyclopropyl)-phenylethynyl]-benzoic acid

수율 50.1%

용매

ethanol

tetrahydrofuran

반응 조건

실험 절차

Using General Procedure I; a solution of ethyl 4-[4-(1-benzylamino-cyclopropyl)-phenylethynyl]-benzoate (Compound 111, 75.0 mg, 0.19 mmol) in ethanol (4 mL) and tetrahydrofuran (4 mL) was treated with NaOH (80.0 mg, 2.0 mmols, 2.0 mL of a 1N aqueous solution) and stirred overnight at room temperature. Work-up afforded 35.0 mg (50%) of the title compound as a colorless solid.

출처