반응 #52482

반응 방정식

tert-butyl [1-(4-bromophenyl)-cyclopropyl]-carbamate

Intermediate 115

tert-butyl [1-(4-bromophenyl)-cyclopropyl]-carbamate

HCl

→

1-(4-Bromophenyl)-cyclopropylamine

용매

MeOH

THF

반응 조건

후처리

1. 1
   기타The reaction was quenched
2. 2
   추출The mixture was extracted with Et2O
3. 3
   세척the combined organic layers were washed with H2O and saturated aqueous NaCl
4. 4
   건조before being dried (MgSO4)
5. 5
   농축concentrated under reduced pressure
6. 6
   기타The title compound 613 mg (85%) was used without further purification

실험 절차

To a solution of tert-butyl [1-(4-bromophenyl)-cyclopropyl]-carbamate (Intermediate 115, 1.08 g, 3.40 mmols) in 20 mL MeOH and 20 mL THF was added 20 mL of 3M aqueous HCl. The solution was warmed to 35° C. for 3 hours and then stirred for 17 h at 25° C. The reaction was quenched by adjusting the pH of the solution to 12 with 3M aqueous NaOH. The mixture was extracted with Et2O and the combined organic layers were washed with H2O and saturated aqueous NaCl before being dried (MgSO4) and concentrated under reduced pressure. The title compound 613 mg (85%) was used without further purification.

출처