반응 #52481

반응 방정식

1-(4-bromophenyl)-cyclopropanecarboxylic acid

Intermediate 114

1-(4-bromophenyl)-cyclopropanecarboxylic acid

diphenylphosphoryl azide

triethylamine

tert-BuOH

→

title compound

수율 67.0%

Tert-butyl [1-(4-bromophenyl)-cyclopropyl]-carbamate

수율 67.0%

반응 조건

후처리

1. 1
   온도to reflux for 17 h
2. 2
   농축The solution was concentrated under reduced pressure
3. 3
   workup.DISSOLUTIONthe residue dissolved in EtOAc
4. 4
   세척washed with 5% aqueous HCl, H2O, saturated aqueous NaHCO3, and saturated aqueous NaCl
5. 5
   건조before being dried over MgSO4

실험 절차

A solution of 1-(4-bromophenyl)-cyclopropanecarboxylic acid (Intermediate 114, 2.32 g, 9.62 mmols), diphenylphosphoryl azide (2.65 g, 9.62 mmols), triethylamine (973.0 mg, 9.62 mmols) in 40 mL tert-BuOH (distilled from Na°) was heated to reflux for 17 h. The solution was concentrated under reduced pressure and the residue dissolved in EtOAc and washed with 5% aqueous HCl, H2O, saturated aqueous NaHCO3, and saturated aqueous NaCl before being dried over MgSO4. Concentration of the dry solution under reduced pressure and column chromatography (5-10% EtOAc—hexanes) afforded 2.01 g (67%) of the title compound as a colorless solid.

출처