반응 #52480

반응 방정식

HCl

KOH

ethylene glycol

1-(4-bromophenyl)-cyclopropanecarbonitrile

Intermediate 113

1-(4-bromophenyl)-cyclopropanecarbonitrile

→

title compound

수율 97.0%

1-(4-Bromophenyl)-cyclopropanecarboxylic acid

수율 97.0%

용매

H2O

반응 조건

후처리

1. 1
   온도cooled to room temperature
2. 2
   여과the solid was collected by filtration
3. 3
   세척washed with H2O
4. 4
   기타The colorless solid was dried under reduced pressure

실험 절차

To a solution of KOH (6.06 g, 0.11 mol) in 10 mL of H2O was added 40 mL of ethylene glycol and 1-(4-bromophenyl)-cyclopropanecarbonitrile (Intermediate 113, 10.0 g, 0.45 mol). This solution was heated to 135-140° C. for 4 h, cooled to room temperature, and then poured into a mixture of 100 mL ice and 10% aqueous HCl. The resulting mixture was allowed to stand overnight at 5° C., the solid was collected by filtration and washed with H2O. The colorless solid was dried under reduced pressure to give 10.6 g (97%) of the title compound.

출처