반응 #524394

반응 방정식

sodium iodide

2-Cyclohexylethyl bromide

4-benzamidopiperidine

diisopropylamine

→

1-[2-(Cyclohexyl)ethyl]-4-benzamidopiperidine

용매

dimethylformamide

water

dimethylformamide

반응 조건

후처리

1. 1
   온도cooled
2. 2
   추출extracted with methylene chloride
3. 3
   세척The washed
4. 4
   기타dried extracts
5. 5
   기타were evaporated
6. 6
   기타the solid residue was recrystallised from ethanol
7. 7
   기타to give the product (1.25 g.), m.p. 174°-5° C. (Found: C, 76.4; H, 9.5; N, 8.9 C20H30N2O requires C, 76.4; H, 9.6; N, 8.9%)

실험 절차

2-Cyclohexylethyl bromide (1.9 g.) in dimethylformamide (10 ml.) was added to 4-benzamidopiperidine (2.2g.), diisopropylamine (4 ml.) and a trace of sodium iodide in dimethylformamide (10 ml). The mixture was heated at 70° C. for 16 hours, cooled, poured into water, and extracted with methylene chloride. The washed and dried extracts were evaporated and the solid residue was recrystallised from ethanol to give the product (1.25 g.), m.p. 174°-5° C. (Found: C, 76.4; H, 9.5; N, 8.9 C20H30N2O requires C, 76.4; H, 9.6; N, 8.9%).

출처