반응 #52425

반응 방정식

1-ethynyl-4-(1-isopropoxycyclopropyl)-benzene

Intermediate 66

1-ethynyl-4-(1-isopropoxycyclopropyl)-benzene

methyl-(4-iodophenyl)-acetate

4-iodo phenyl acetic acid methyl ester

Reagent B

4-iodo phenyl acetic acid methyl ester

→

title compound

수율 70.2%

Methyl{4-[4-(1-isopropoxycyclopropyl)-phenylethynyl]-phenyl}-acetate

수율 70.2%

용매

triethylamine

반응 조건

후처리

1. 1
   기타sparged with argon for 5 minutes

실험 절차

Using General Procedure F; 1-ethynyl-4-(1-isopropoxycyclopropyl)-benzene (Intermediate 66, 95.0 mg, 0.45 mmol) and methyl-(4-iodophenyl)-acetate (Reagent B, 131.0 mg, 0.45 mmol) in triethylamine (6 mL) was treated with copper(I)iodide (30.0 mg, 0.16 mmol) and sparged with argon for 5 minutes. Dichlorobis(triphenylphosphine)palladium(II) (111 mg, 0.16 mmol) was added and the reaction mixture was stirred overnight at room temperature. Column chromatography (2-8% EtOAc—hexanes) afforded 110.0 mg (70%) of the title compound as an orange oil.

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