반응 #52382

반응 방정식

8-cyclopropyl-6-ethynyl-2,2,4,4-tetramethylchroman

triethyl amine

ethyl-2-fluoro-4-iodo phenyl acetate

2-fluoro-4-iodo phenyl acetic acid ethyl ester

Reagent C

2-fluoro-4-iodo phenyl acetic acid ethyl ester

Intermediate 34

8-cyclopropyl-6-ethynyl-2,2,4,4-tetramethylchroman

→

title compound

[4-(8-Cyclopropyl-2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-2-fluorophenyl] acetic acid ethyl ester

용매

tetrahydrofuran

반응 조건

실험 절차

Following general procedure F and using 8-cyclopropyl-6-ethynyl-2,2,4,4-tetramethylchroman (Intermediate 34, 0.096 g, 0.38 mmol), ethyl-2-fluoro-4-iodo phenyl acetate (Reagent C, 0.104 g, 0.34 mmol), triethyl amine (3 mL), tetrahydrofuran (3 mL), copper(I)iodide (0.020 g, 0.11 mmol) and dichlorobis(triphenylphosphine)palladium(II) (0.060 g, 0.085 mmol) the title compound was obtained (0.14 g, 85%).

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