반응 #52378

반응 방정식

8-cyclopropyl-6-ethynyl-2,2,4,4-tetramethylchroman

triethyl amine

ethyl-4-iodo-benzoate

Reagent A

ethyl-4-iodo-benzoate

tetrahydrofuran

Intermediate 34

8-cyclopropyl-6-ethynyl-2,2,4,4-tetramethylchroman

→

title compound

4-(8-Cyclopropyl-2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-benzoic acid ethyl ester

용매

ethyl acetate

hexane

반응 조건

실험 절차

Following general procedure F and using 8-cyclopropyl-6-ethynyl-2,2,4,4-tetramethylchroman (Intermediate 34, 0.1 g, 0.38 mmol), ethyl-4-iodo-benzoate (Reagent A, 0.1 g, 0.34 mmol), triethyl amine (5 mL), tetrahydrofuran(10 mL), copper(I)iodide(0.025 g, 0.13 mmol) and dichlorobis(triphenylphosphine)palladium(II) (0.075 g, 0.11 mmol) followed by flash column chromatography over silica gel (230-400 mesh) using 5-10% ethyl acetate in hexane as the eluent, the title compound was obtained (0.135 g, 89%).

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