반응 #52377

ord-931d8dd58b1e4edd80381b11ce10f3fb

반응 방정식

CC1(C)CC(C)(C)c2cc(C#C[Si](C)(C)C)cc(C3CC3)c2O1
8-cyclopropyl-6-trimethylsilanylethynyl-2,2,4,4-tetramethyl chroman
CC1(C)CC(C)(C)c2cc(C#C[Si](C)(C)C)cc(C3CC3)c2O1
Intermediate 33
CC1(C)CC(C)(C)c2cc(C#C[Si](C)(C)C)cc(C3CC3)c2O1
8-cyclopropyl-6-trimethylsilanylethynyl-2,2,4,4-tetramethyl chroman
O=C([O-])[O-].[K+].[K+]
potassium carbonate
→
C#Cc1cc(C2CC2)c2c(c1)C(C)(C)CC(C)(C)O2
title compound
C#Cc1cc(C2CC2)c2c(c1)C(C)(C)CC(C)(C)O2
8-Cyclopropyl-6-ethynyl-2,2,4,4-tetramethyl chroman

반응물

CC1(C)CC(C)(C)c2cc(C#C[Si](C)(C)C)cc(C3CC3)c2O1
8-cyclopropyl-6-trimethylsilanylethynyl-2,2,4,4-tetramethyl chroman
CC1(C)CC(C)(C)c2cc(C#C[Si](C)(C)C)cc(C3CC3)c2O1
Intermediate 33
CC1(C)CC(C)(C)c2cc(C#C[Si](C)(C)C)cc(C3CC3)c2O1
8-cyclopropyl-6-trimethylsilanylethynyl-2,2,4,4-tetramethyl chroman
O=C([O-])[O-].[K+].[K+]
potassium carbonate

시약

없음

용매

CO
methanol

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Following general procedure E and using 8-cyclopropyl-6-trimethylsilanylethynyl-2,2,4,4-tetramethyl chroman (Intermediate 33, 0.17 g, 0.68 mmol), methanol and potassium carbonate (0.2 g, 1.47 mmol) the title compound was obtained as an oil (0.064 g, 47%).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06855512B2uspto-grants-2005_02