반응 #52368

반응 방정식

6-ethynyl-2,2,4,4-tetramethylchroman

tetrahydrofuran

Reagent C

2-fluoro-4-iodo phenyl acetic acid ethyl ester

triethyl amine

ethyl-2-fluoro-4-iodo phenyl acetate

2-fluoro-4-iodo phenyl acetic acid ethyl ester

→

title compound

[2-Fluoro-4-(2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)phenyl] acetic acid ethyl ester

용매

hexane

ethyl acetate

반응 조건

실험 절차

Following general procedure F and using 6-ethynyl-2,2,4,4-tetramethylchroman (0.204 g, 0.95 mmol), ethyl-2-fluoro-4-iodo phenyl acetate (Reagent C, 0.263 g, 0.86 mmol), triethyl amine, tetrahydrofuran, copper(I)iodide (0.025 g, 0.13 mmol) and dichlorobis(triphenylphosphine)palladium(II) (0.075 g, 0.11 mmol) followed by flash column chromatography over silica gel (230-400 mesh) using 5-10% ethyl acetate in hexane as the eluent, the title compound was obtained (0.21 g, 62%).

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