반응 #52366

반응 방정식

6-ethynyl-2,2,4,4-tetramethylchroman

tetrahydrofuran

Reagent G

methyl-2-fluoro-4-iodo-benzoate

triethyl amine

methyl-2-fluoro-4-iodo-benzoate

→

title compound

2-Fluoro-4-(2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-benzoic acid methyl ester

용매

hexane

ethyl acetate

반응 조건

실험 절차

Following general procedure F and using 6-ethynyl-2,2,4,4-tetramethylchroman (0.11 g, 0.51 mmol), methyl-2-fluoro-4-iodo-benzoate (Reagent G, 0.14 g, 0.51 mmol), triethyl amine (5 mL), tetrahydrofuran(10 mL), copper(I)iodide(0.030 g, 0.16 mmol) and dichlorobis(triphenylphosphine)palladium(II) (0.110 g, 0.16 mmol) followed by flash column chromatography over silica gel (230-400 mesh) using 5-10% ethyl acetate in hexane as the eluent, the title compound was obtained (0.14 g, 79%).

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