반응 #523407

반응 방정식

2propargylaminoacetaldehyde

5-cyclopropyl-1,3,4-thiadiazol-2-yl isocyanate

→

2-[1-propargyl-3-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)ureido]-acetaldehyde

용매

ethyl acetate

반응 조건

후처리

1. 1
   기타equipped with a mechanical stirrer
2. 2
   온도reflux condenser
3. 3
   온도The reaction mixture is heated
4. 4
   온도at reflux for a period of about 2 hours

실험 절차

A mixture of 5-cyclopropyl-1,3,4-thiadiazol-2-yl isocyanate dimer (7 grams), the dimethyl acetal of 2propargylaminoacetaldehyde (5 grams) and ethyl acetate (50 ml) were charged into a glass reaction vessel equipped with a mechanical stirrer and reflux condenser. The reaction mixture is heated at reflux for a period of about 2 hours. After this time the mixture is stripped of solvent under reduced pressure to yield the desired product the dimethyl acetal of 2-[1-propargyl-3-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)ureido]-acetaldehyde as an oil.

출처