반응 #52334

반응 방정식

6-methyl-2-nitro-pyridin-3-ol

→

title compound

2-Amino-6-methyl-pyridin-3-ol

용매

ethyl acetate

반응 조건

후처리

1. 1
   여과The mixture was filtered through Celite
2. 2
   세척washed with methanol/ethylacetate (5%)
3. 3
   세척The filtrate and washing
4. 4
   농축concentrated

실험 절차

A mixture of 6-methyl-2-nitro-pyridin-3-ol (18.5 g, 0.120 mmol), 10% palladium on activated carbon (1.35 g), and ethyl acetate (240 mL) was hydrogenated for 3 days. The mixture was filtered through Celite and washed with methanol/ethylacetate (5%). The filtrate and washing were combined and concentrated to give the title compound (14.7 g, 99% yield) as a pale brown solid. 1H NMR (DMSO-d6) δ 9.19 (bs, 1H), 6.73 (d, 1H, J=7.6 Hz), 6.12 (d, 1H, J=7.6 Hz), 5.36 (bs, 2H), 2.15 (s, 3H).

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