반응 #52329

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3-bromo-5-(2,2,2-trifluoro-ethoxy)-pyridine

3,3,3-triethoxypropyne

→

title compound

수율 46.0%

3-Triethoxyprop-1-ynyl-5-(2,2,2-trifluor-ethoxy)-pyridine

수율 46.0%

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실험 절차

The title compound was synthesized from 3-bromo-5-(2,2,2-trifluoro-ethoxy)-pyridine and 3,3,3-triethoxypropyne using the procedure described in Example 43, step (e), in 46% yield. 1H NMR (CDCl3) δ 8.44 (bs, 1H), 8.35 (bs, 1H), 7.34 (m, 1H), 4.40 (q, 2H, J=7.9 Hz), 3.76 (q, 6H, J=7.1 Hz), 1.28 (t, 9H, J=7.1 Hz).

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