반응 #52308

반응 방정식

Sodium thiomethoxide

3,5-dibromopyridine

→

title compound

수율 89.0%

3-Bromo-5-methylsulfanyl-pyridine

수율 89.0%

용매

ethyl acetate

DMF

반응 조건

후처리

1. 1
   세척washed several times with brine
2. 2
   건조The extracts were dried over magnesium sulfate
3. 3
   기타the solvent was removed under reduced pressure
4. 4
   기타The crude material was chromatographed on silica (10% ethyl acetate/hexanes)

실험 절차

Sodium thiomethoxide (1.6 g, 23 mmol) was added to a solution of 3,5-dibromopyridine (5 g, 21 mmol) in DMF (25 mL). After stirring overnight at room temperature, the reaction mixture was diluted with ethyl acetate and washed several times with brine. The extracts were dried over magnesium sulfate and the solvent was removed under reduced pressure. The crude material was chromatographed on silica (10% ethyl acetate/hexanes) to give the title compound (3.8 g, 89% yield) as a clear oil.

출처