반응 #5229

반응 방정식

2-Phenyl-pyrrolo[3,4-c]quinolin-3(1H)-one

m-chloroperbenzoic acid

→

2-Phenyl-pyrrolo[3,4-c]quinoline-3(1H),4(5H)-dione

용매

methylene chloride

methylene chloride

반응 조건

후처리

1. 1
   세척washed with sodium carbonate solution
2. 2
   건조The organic layer was dried over magnesium sulfate
3. 3
   기타the solvent was removed in vacuo
4. 4
   기타The reaction was quenched with methanol
5. 5
   농축The reaction mixture was concentrated in vacuo
6. 6
   추출the resulting aqueous solution was extracted with ethyl acetate
7. 7
   건조the organic layer was dried over magnesium sulfate
8. 8
   기타the solvent was removed in vacuo
9. 9
   기타The residue was triturated with ether

실험 절차

A mixture of 2-Phenyl-pyrrolo[3,4-c]quinolin-3(1H)-one (60 mg), and m-chloroperbenzoic acid (105 mg) in 3 mL of methylene chloride was kept at room temperature for 24 h. The mixture was diluted with methylene chloride and washed with sodium carbonate solution. The organic layer was dried over magnesium sulfate and the solvent was removed in vacuo. The residue was heated at 50° C. for 3 h with 1 mL of acetic anhydride. The reaction was quenched with methanol and made basic with ammonium hydroxide. The reaction mixture was concentrated in vacuo, and the resulting aqueous solution was extracted with ethyl acetate, the organic layer was dried over magnesium sulfate and the solvent was removed in vacuo. The residue was triturated with ether to afford 2-Phenyl-pyrrolo[3,4-c]quinoline-3(1H),4(5H)-dione (Compound 16) as a white solid.

출처