반응 #52236

반응 방정식

1-Boc-isonipecotic acid

BH3-THF

→

l-Boc-piperidine-4-methanol

수율 85.0%

용매

THF

반응 조건

후처리

1. 1
   온도to warm to room temperature for 12 h
2. 2
   기타The mixture was carefully quenched with water
3. 3
   workup.ADDITIONdiluted with ethyl acetate
4. 4
   추출The water layer was extracted with ethyl acetate
5. 5
   세척washed with brine
6. 6
   건조dried (Na2SO4)
7. 7
   여과filtered
8. 8
   농축concentrated

실험 절차

1-Boc-isonipecotic acid (10.0 g, 214 mmol) was dissolved in THF (400 mL) and cooled to 0° C. A solution of BH3-THF (180 mL, 1 N in THF, 180 mmol) was added slowly. The mixture stirred for 1 h at 0° C. and was allowed to warm to room temperature for 12 h. The mixture was carefully quenched with water and diluted with ethyl acetate. The water layer was extracted with ethyl acetate. The organic layers were combined, washed with brine, dried (Na2SO4), filtered and concentrated to provide l-Boc-piperidine-4-methanol (7.98 g, 85%) as a white solid.

출처