반응 #521946

반응 방정식

2,2'-bipyridinium chlorochromate

2-isopropylcyclohexanol

→

2-isopropylcyclohexanone

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   workup.ADDITIONTo a suspension of 4.0 g
2. 2
   기타The resulting reaction mixture
3. 3
   workup.STIRRINGis stirred for 4 hours
4. 4
   여과filtered through a Hirsch funnel
5. 5
   세척The resulting clear filtrate is washed with 5% hydrochloric acid and 10% sodium carbonate
6. 6
   건조dried over magnesium sulfate
7. 7
   기타The drying agent is then removed
8. 8
   기타the solvent evaporated
9. 9
   기타to yield a colorless oil which
10. 10
    workup.DISTILLATIONis distilled via Kugelrohr

실험 절차

To a suspension of 4.0 g. (13.7 mmole) of 2,2'-bipyridinium chlorochromate in 15 ml of dichloromethane is added, while stirring, 0.5 g. (3.5 mmole) of 2-isopropylcyclohexanol in 10 ml of dichloromethane. The resulting reaction mixture is stirred for 4 hours and then filtered through a Hirsch funnel packed with 2 cm of Celite®. The resulting clear filtrate is washed with 5% hydrochloric acid and 10% sodium carbonate, and dried over magnesium sulfate. The drying agent is then removed and the solvent evaporated to yield a colorless oil which is distilled via Kugelrohr to yield pure 2-isopropylcyclohexanone in a typical yield of 0.425 g. which is 86% of theoretical yield.

출처