반응 #521787

반응 방정식

(+)-1α-ethyl-1β- carboxyethyl-6-carboxy-1,2,3,4,6,7-hexahydro-12H-indolo(2,3-a)-quinolizin-5-ium perchlorate

decalin

→

title compound

수율 97.2%

(-)-1α-Ethyl-1β- carboxyethyl-1,2,3,4,6,7-hexahydro-12H-indolo(2,3-a)quinolizin-5-ium perchlorate

수율 97.2%

반응 조건

후처리

1. 1
   온도After cooling the reaction mixture
2. 2
   여과is filtered
3. 3
   기타the solid obtained
4. 4
   세척is washed decalin-free with three 5-ml
5. 5
   건조portions of ether and is dried

실험 절차

1000 mg. (2.13 mmoles) of (+)-1α-ethyl-1β- carboxyethyl-6-carboxy-1,2,3,4,6,7-hexahydro-12H-indolo(2,3-a)-quinolizin-5-ium perchlorate in 15 ml. of decalin are heated at 160° to 170° C. for 25 minutes, with stirring. The substance melts accompanied by gas evolution. After cooling the reaction mixture is filtered, the solid obtained is washed decalin-free with three 5-ml. portions of ether and is dried. 880 mg. of the title compound are obtained. Yield: 97.2% [α]D25 =-19°.

출처