반응 #52166
ord-82bcd2e31e4742e288da7ae9c3316792
반응 방정식
반응 조건
온도
50°CELSIUS
상세 조건
See reaction.notes.procedure_details.
후처리
- 1농축The residue was concentrated in vacuo
- 2기타the crude 3,5-dichloropyridine-4-carboxylic acid chloride was used in Step E without further purification
실험 절차
3,5-Dichloropyridine-4-carboxylic acid (0.5 g, 2.6 mmol; Reference Example 1) was dissolved in CH2Cl2 (1.75 mL) and DMF (50 μL). Thionyl chloride (0.21 mL, 2.86 mL) was added and the reaction mixture was heated at 50° C. for 20 h. The residue was concentrated in vacuo. The formation of the acid chloride was observed by TLC (50% EtOAc/hexane) and the crude 3,5-dichloropyridine-4-carboxylic acid chloride was used in Step E without further purification.