반응 #5214

반응 방정식

trifluoroacetic acid

trifluoromethanesulfonic acid

3-(4-methoxybenzylthio)pyrrolidin-2-one

→

title compound

3-Mercapto-2-pyrrolidinone trifluoromethanesulfonate

용매

anisole

반응 조건

후처리

1. 1
   농축At the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure
2. 2
   기타to leave a residue, which
3. 3
   기타was purified by column chromatography through silica gel
4. 4
   세척eluted with a 10:1 by volume mixture of ethyl acetate and methanol

실험 절차

20 ml of trifluoroacetic acid and 0.41 ml of trifluoromethanesulfonic acid were added, whilst ice-cooling, to a solution of 949 mg of 3-(4-methoxybenzylthio)pyrrolidin-2-one in 4 ml of anisole, and then the mixture was stirred at room temperature for 30 minutes. At the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure to leave a residue, which was purified by column chromatography through silica gel, eluted with a 10:1 by volume mixture of ethyl acetate and methanol, to give 728 mg of the title compound as an oil.

출처