반응 #5213

반응 방정식

methyl fluorosulfonate

(6S, 8S)-8-(4-methoxybenzylthio)-4-methyl-5-oxo-1,4-diazabicyclo-[4.3.0]nonane

→

title compound

(6S, 8S)-1,4-Dimethyl-8-(4-methoxybenzylthio)-5-oxo-4-aza-1-azoniabicyclo[4.3.0]nonane fluorosulfonate

용매

diethyl ether

methylene chloride

반응 조건

후처리

1. 1
   여과the resulting crystals were collected by filtration
2. 2
   기타dried under reduced pressure

실험 절차

461 μl of methyl fluorosulfonate was added, whilst ice-cooling, to a solution of 1.71 g of (6S, 8S)-8-(4-methoxybenzylthio)-4-methyl-5-oxo-1,4-diazabicyclo-[4.3.0]nonane dissolved in 60 ml of methylene chloride, and the mixture was stirred at room temperature for 2 hours. At the end of this time, the mixture was diluted with diethyl ether, and the resulting crystals were collected by filtration and dried under reduced pressure, to afford 2.09 g of the title compound as colorless crystals, melting at 208°-210° C.

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