반응 #52100

반응 방정식

5-bromo-2-chloro-N-(2-oxo-ethyl)-benzamide

hydroxylamine hydrochloride

sodium acetate

→

title compound

수율 94.0%

5-Bromo-2-chloro-N-[2-(N-formyl-N-hydroxy-amino)-ethyl]-benzamide

수율 94.0%

용매

MeOH

반응 조건

후처리

1. 1
   기타the MeOH was removed in vacuo
2. 2
   세척The residue was washed with water
3. 3
   기타was dried in vacuo for 18 h
4. 4
   기타used without further purification

실험 절차

To a solution of 5-bromo-2-chloro-N-(2-oxo-ethyl)-benzamide (11.8 g, 42.5 mmol) in MeOH (400 mL) was added hydroxylamine hydrochloride (5.9 g, 85 mmol) and sodium acetate (6.97 g, 85 mmol). The mixture was stirred 18 h and the MeOH was removed in vacuo. The residue was washed with water and was dried in vacuo for 18 h and used without further purification to provide the title compound (11.7 g, 94%) as a white solid. ESMS: M+H=291.

출처