반응 #52069

반응 방정식

2-methyl-2-p-tolyl-propionic acid ethyl ester

lithium aluminum hydride

→

2-methyl-2-p-tolyl-propan-1-ol

수율 99.8%

용매

THF

반응 조건

후처리

1. 1
   기타the reaction was quenched by consecutive addition of water (0.1 mL), 15% NaOH (0.1 mL), and water (0.3 mL)
2. 2
   workup.ADDITIONThe reaction was diluted with EtOAc
3. 3
   건조dried (MgSO4)
4. 4
   여과filtered
5. 5
   농축concentrated

실험 절차

To a solution of 2-methyl-2-p-tolyl-propionic acid ethyl ester (510 mg, 2.47 mmol) in THF (10 mL) at 0° C. was added lithium aluminum hydride (1M in Et2O, 2.6 mL, 2.6 mmol). The reaction was stirred for 0.5 h and the reaction was quenched by consecutive addition of water (0.1 mL), 15% NaOH (0.1 mL), and water (0.3 mL). The reaction was diluted with EtOAc, dried (MgSO4), filtered and concentrated to yield 2-methyl-2-p-tolyl-propan-1-ol (405 mg). 1H NMR (400 MHz, CDCl3) δ 7.27 (d, 2H), 7.15 (d, 2H), 3.58 (s, 2H), 2.32 (s, 3H), 1.31 (s, 6H); MS 165 (M+1).

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