반응 #5193

반응 방정식

methyl fluorosulfonate

(2S, 4S)-2-carbamoyl-4-(4-methoxybenzylthio)-1-ethylpyrrolidine

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title compound

(2S, 4S)-2-Carbamoyl-4-(4-methoxybenzylthio)-1-ethyl-1-methylpyrrolidinium fluorosulfonate

용매

methylene chloride

반응 조건

후처리

1. 1
   기타At the end of this time, the solvent was removed by distillation under reduced pressure
2. 2
   세척the residue was washed repeatedly by decantation with diethyl ether
3. 3
   기타dried under reduced pressure

실험 절차

0.43 ml of methyl fluorosulfonate was added, whilst ice-cooling, to a solution of 1.44 g of (2S, 4S)-2-carbamoyl-4-(4-methoxybenzylthio)-1-ethylpyrrolidine dissolved in 30 ml of dry methylene chloride and the mixture was stirred at room temperature for 2 hours. At the end of this time, the solvent was removed by distillation under reduced pressure, and the residue was washed repeatedly by decantation with diethyl ether and dried under reduced pressure to afford 2.0 g of the title compound as an oil.

출처