반응 #5191

반응 방정식

hydrochloric acid

sodium hydroxide

(2S, 4S)-4-(4-methoxybenzylthio)-2-methoxycarbonyl-1-methylpyrrolidine

→

(2S, 4S)-2-carboxy-4-(4-methoxybenzylthio)-1-methylpyrrolidine

수율 120.2%

용매

methanol

반응 조건

후처리

1. 1
   기타the reaction mixture was freed from the solvent by evaporation under reduced pressure
2. 2
   기타the residue was dried
3. 3
   농축concentrated by evaporation under reduced pressure

실험 절차

5.32 ml of a 1N aqueous solution of sodium hydroxide were added to a solution of 1.31 g of (2S, 4S)-4-(4-methoxybenzylthio)-2-methoxycarbonyl-1-methylpyrrolidine dissolved in 11 ml of methanol, and the mixture was stirred at room temperature for 2 hours. At the end of this time, it was neutralized with 5.32 ml of 1N aqueous hydrochloric acid, and the reaction mixture was freed from the solvent by evaporation under reduced pressure, and the residue was dried and concentrated by evaporation under reduced pressure, to afford 1.5 g of crude (2S, 4S)-2-carboxy-4-(4-methoxybenzylthio)-1-methylpyrrolidine.

출처