반응 #5185
ord-757ef081a3af49d2a9a2d7813d18eacf
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1workup.WAITat 25° C. for 2 hours
- 2기타the crystals which precipitated
- 3여과were collected by filtration
실험 절차
106 ml of a 4N ethyl acetate solution of hydrogen chloride were added, whilst ice-cooling, to a solution of 27.50 g of (3R)-1-t-butoxycarbonyl-3-(4-methoxybenzylthio)pyrrolidine [prepared as described in step (2) above] dissolved in 100 ml of ethyl acetate, and the mixture was stirred at 0° to 5° C. for 30 minutes and then at 25° C. for 2 hours. At the end of this time, the mixture was diluted with 200 ml of diisopropyl ether, and the crystals which precipitated were collected by filtration, to give 20.84 g of the title compound as colorless crystals, melting at 125°-126° C.