반응 #51843

반응 방정식

4-tert-butoxycarbonylamino-1-(5-piperid-1-ylcarbonyl-2-pyridyl)piperidine

trifluoroacetic acid

→

4-amino-1-(5-piperid-1-ylcarbonyl-2-pyridyl)piperidine

용매

dichloromethane

반응 조건

후처리

1. 1
   농축The reaction medium is concentrated under reduced pressure
2. 2
   추출The aqueous phase is extracted five times with dichloromethane
3. 3
   건조The organic phases are dried over magnesium sulfate
4. 4
   농축concentrated under reduced ressure

실험 절차

A solution of 0.475 g of 4-tert-butoxycarbonylamino-1-(5-piperid-1-ylcarbonyl-2-pyridyl)piperidine (1.24 mmol) and 5 ml of trifluoroacetic acid in 20 ml of dichloromethane is stirred for 1 hour. The reaction medium is concentrated under reduced pressure and then taken up in dichloromethane. The solution is basified (pH=9) using saturated aqueous sodium carbonate solution. The aqueous phase is extracted five times with dichloromethane. The organic phases are dried over magnesium sulfate and concentrated under reduced ressure. The 4-amino-1-(5-piperid-1-ylcarbonyl-2-pyridyl)piperidine is obtained in the form of an oil (0.310 g, 88%). [M+H+]=289.4

출처