반응 #51842

반응 방정식

water

triethylamine

6-chloronicotinamide

dimethylformamide

→

title compound

4-tert-Butoxycarbonylamino-1-(5-aminocarbonyl-2-pyridyl)piperidine

반응 조건

후처리

1. 1
   온도After cooling
2. 2
   여과the product is filtered off

실험 절차

A mixture of 3 g (0.015 mol) of the product of preparation 1, 1.5 g (0.015 mol) of triethylamine and 2.34 g (0.015 mol) of 6-chloronicotinamide in 60 ml of dimethylformamide is heated at 80° C. for 18 hours. After cooling, water is added and the product is filtered off. 2.8 g of the title compound are thus obtained. m.p. 255° C. dec.

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