반응 #51839

반응 방정식

water

hydantoin

potassium carbonate

benzyl bromoacetate

→

phenylmethyl 2-(2,5-dioxoimidazolidinyl)acetate

수율 60.0%

용매

DMF

반응 조건

후처리

1. 1
   추출the mixture was extracted with ethyl acetate
2. 2
   세척The organic phase was washed with 5% aqueous citric acid solution and brine
3. 3
   건조The organic phase was dried over anhydrous magnesium sulfate
4. 4
   여과filtered
5. 5
   기타evaporated under reduced pressure
6. 6
   세척The crystalline residue was washed with diethyl ether
7. 7
   기타dried

실험 절차

To a solution of hydantoin (10.0 g, 0.10 mol) in DMF (100 ml) at 60° C. were added potassium carbonate (20.7 g, 0.15 mol) and benzyl bromoacetate (18.9 ml, 0.12 mol). After stirring the mixture at 60° C. overnight, the reaction mixture was poured into water (250 ml) and the mixture was extracted with ethyl acetate. The organic phase was washed with 5% aqueous citric acid solution and brine. The organic phase was dried over anhydrous magnesium sulfate, filtered and evaporated under reduced pressure. The crystalline residue was washed with diethyl ether, and dried to give phenylmethyl 2-(2,5-dioxoimidazolidinyl)acetate (14.9 g).

출처