반응 #5182

반응 방정식

methyl fluorosulfonate

(2S, 4S)-2-(N,N-dimethylcarbamoyl)-4-(4-methoxybenzylthio)-1-methylpyrrolidine

→

title compound

(2S, 4S)-2-(N,N-Dimethylcarbamoyl)-4-(4-methoxybenzylthio)-1,1-dimethylpyrrolidinium fluorosulfonate

용매

methylene chloride

반응 조건

후처리

1. 1
   workup.DISTILLATIONAt the end of this time, the solvent was distilled off under reduced pressure
2. 2
   세척The residue was repeatedly washed by decantation with hexane
3. 3
   기타dried under reduced pressure

실험 절차

139 μl of methyl fluorosulfonate were added, whilst ice-cooling, to a solution of 190 mg of (2S, 4S)-2-(N,N-dimethylcarbamoyl)-4-(4-methoxybenzylthio)-1-methylpyrrolidine [prepared as described in step (5) or (11) above] dissolved in 3.8 ml of methylene chloride, and the mixture was stirred at room temperature for 2 hours. At the end of this time, the solvent was distilled off under reduced pressure. The residue was repeatedly washed by decantation with hexane and dried under reduced pressure, to give 356 mg of the title compound as an oil.

출처