반응 #5181

반응 방정식

hydrochloric acid

sodium hydroxide

(2S, 4S)-4-(4-methoxybenzylthio)-2-methoxycarbonyl-1-methylpyrrolidine

→

(2S, 4S)-2-carboxy-4-(4-methoxybenzylthio)-1-methylpyrrolidine

용매

methanol

반응 조건

후처리

1. 1
   기타The solvent was then removed by distillation under reduced pressure
2. 2
   기타the residue was dried

실험 절차

1.92 ml of a 1N aqueous solution of sodium hydroxide was added to a solution of 378 mg of (2S, 4S)-4-(4-methoxybenzylthio)-2-methoxycarbonyl-1-methylpyrrolidine [prepared as described in step (10) above] dissolved in 3.84 ml of methanol, and the mixture was stirred at room temperature for 3 hours, At the end of this time, the mixture was neutralized by the addition of 1.92 ml of 1N aqueous hydrochloric acid. The solvent was then removed by distillation under reduced pressure, and the residue was dried, to give crude (2S, 4S)-2-carboxy-4-(4-methoxybenzylthio)-1-methylpyrrolidine.

출처