반응 #517675

반응 방정식

N-(3-bromophenyl)-4,6-quinazolindiamine

trans-crotonoyl chloride

→

N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-(E)-2-butenamide

용매

pyridine

ether

반응 조건

후처리

1. 1
   온도cooling for 2 hours
2. 2
   기타the solvents were removed at reduced pressure
3. 3
   workup.ADDITIONThe residue was treated with water
4. 4
   기타the resulting solid recrystallized from n-butanol

실험 절차

A solution of 1.6 g of N-(3-bromophenyl)-4,6-quinazolindiamine in 15 ml of pyridine was cooled in an ice bath and a solution of 0.57 ml of trans-crotonoyl chloride in 6 ml of ether was added dropwise. After stirring and cooling for 2 hours, the solvents were removed at reduced pressure. The residue was treated with water and the resulting solid recrystallized from n-butanol to give 0.69 g of N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-(E)-2-butenamide: mp=153-160° C., mass spectrum (m/e): M+H 383, 385.

출처