반응 #51763

반응 방정식

5-tert-butyl-2-nitro-phenylamine

ammonium thiocyanate

bromine

→

title compound

5-tert-Butyl-2-nitro-4-thiocyanato-phenylamine

용매

MeOH

반응 조건

후처리

1. 1
   기타The crude reaction mixture
2. 2
   기타was purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents)

실험 절차

The title compound was prepared according to the General Method 13 using 5-tert-butyl-2-nitro-phenylamine (prepared in Example PP-2; 170 g, 876 mmol), ammonium thiocyanate (400 g, 5260 mmol), bromine (140 g, 876 mmol), and MeOH (500 mL). The crude reaction mixture was purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents). MS(APCI): 252 (M+H).

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