반응 #51762

반응 방정식

bromine

5-isopropyl-2-nitro-phenylamine

sodium thiocyanate

sodium bromide

→

title compound

5-Isopropyl-2-nitro-4-thiocyanato-phenylamine

용매

MeOH

반응 조건

후처리

1. 1
   기타The crude reaction mixture
2. 2
   기타was purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents)

실험 절차

The title compound was prepared according to General Method 13 using 5-isopropyl-2-nitro-phenylamine (prepared in Example PP-1; 5.4 g, 30 mmol), sodium thiocyanate (14.6 g, 180 mmol), sodium bromide (3.7 g, 35.99 mmol), bromine (5.75 g, 36.0 mmol), and MeOH (100 mL). The crude reaction mixture was purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents). MS(APCI): 238 (M+H).

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