반응 #51755

반응 방정식

6-tert-Butyl-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

HCl

→

title compound

6-tert-Butyl-2,3-dihydro-1H-indole

용매

CH2Cl2

반응 조건

후처리

1. 1
   기타was cooled to 0° C.
2. 2
   기타The solvents were evaporated
3. 3
   workup.DISSOLUTIONthe residue was dissolved in EtOAc
4. 4
   세척washed with saturated NaHCO3 solution and brine
5. 5
   기타dried
6. 6
   농축(MgSO4.) Concentration

실험 절차

6-tert-Butyl-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (Prepared in Example HH; 12.0 g) in CH2Cl2 (100 mL) was cooled to 0° C. and treated with HCl gas for 10 minutes. The reaction mixture was warmed to room temperature and stirred for 1 hour. The solvents were evaporated; the residue was dissolved in EtOAc, washed with saturated NaHCO3 solution and brine, and dried (MgSO4.) Concentration gave the title compound which was used without any further purification. MS(APCI): 176 (M+H).

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