반응 #51754

반응 방정식

6-tert-Butyl indole-1-carboxylic acid tert-butyl ester

→

title compound

6-tert-Butyl-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

용매

AcOH

반응 조건

후처리

1. 1
   여과The catalyst was filtered
2. 2
   농축the filtrate was concentrated
3. 3
   workup.DISSOLUTIONThe residue was dissolved in EtOAc
4. 4
   세척washed with saturated NaHCO3 solution and brine
5. 5
   건조dried (MgSO4)
6. 6
   농축Concentration

실험 절차

6-tert-Butyl indole-1-carboxylic acid tert-butyl ester (prepared in Example GG; 13.0 g, 48 mmol) was taken up in 500 mL of AcOH. 20% Pd/C (2 g) was added, and the mixture was shaken under a hydrogen atmosphere of 50 psi. The catalyst was filtered, and the filtrate was concentrated. The residue was dissolved in EtOAc, washed with saturated NaHCO3 solution and brine, and dried (MgSO4). Concentration gave the title compound which was used without purification in the next step.

출처