반응 #5172

반응 방정식

methyl fluorosulfonate

(2S, 4S)-4-(4-methoxybenzylthio)-1-methyl-2-methylcarbamoylpyrrolidine

→

title compound

(2S, 4S)-1,1-Dimethyl-2-methylcarbamoyl-4-(4-methoxybenzylthio)pyrrolidinium fluorosulfate

용매

methylene chloride

반응 조건

후처리

1. 1
   workup.WAITat room temperature for 5 hours
2. 2
   기타At the end of this time, the solvent was removed by distillation under reduced pressure
3. 3
   세척the residue was washed repeatedly by decantation with diethyl ether
4. 4
   기타dried

실험 절차

280 μl of methyl fluorosulfonate were added, whilst ice-cooling, to a solution of 210 mg of (2S, 4S)-4-(4-methoxybenzylthio)-1-methyl-2-methylcarbamoylpyrrolidine [prepared as described in step (5) above] dissolved in 30 ml of dry methylene chloride. The mixture was stirred at the same temperature for 30 minutes and then at room temperature for 5 hours. At the end of this time, the solvent was removed by distillation under reduced pressure, and the residue was washed repeatedly by decantation with diethyl ether and dried under reduced rpessure, to afford 281 mg of the title compound as a colorless powder.

출처