반응 #516896

ord-d130bc84710342b38a7c67064366910e

반응 방정식

[Na+].[OH-]
Sodium hydroxide
OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
lactose
→
O.OC[C@H]1O[C@@H](O[C@@H]2[C@@H](CO)O[C@](O)(CO)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O
lactulose

반응물

—
aqueous solution
[Na+].[OH-]
Sodium hydroxide
OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
lactose

시약

없음

반응 조건

온도
70°CELSIUS
상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    workup.ADDITIONby mixing
  2. 2
    온도cooled
  3. 3
    기타The cooled solution was purified by an ion-exchange resin
  4. 4
    농축concentrated
  5. 5
    온도cooled
  6. 6
    기타crystallized
  7. 7
    기타the unreacted lactose is removed

실험 절차

Sodium hydroxide is added to a 10% aqueous solution of commercially available lactose. followed by mixing, and thereafter the mixed solution was heated at 70° C. for 30 minutes and cooled. The cooled solution was purified by an ion-exchange resin, concentrated, cooled and crystallized and the unreacted lactose is removed to give an aqueous solution of lactulose in which the solid content is about 68% (where the solid contains about 79% of lactulose). This aqueous solution is passed through a column filled with a strongly acidic ion-exchange resin and a fraction containing lactulose is collected and concentrated to give an aqueous solution of pure lactulose containing about 68% of solid (where the solid contains about 86% of lactulose). This is the method disclosed in JP 3-169888 A.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06319895B1uspto-grants-2001_11