반응 #5167

반응 방정식

sodium chloride

(2S, 4R)-1-(t-butoxycarbonyl)-4-hydroxy-2-pyrrolidinecarboxylic acid

ethyl chloroformate

methylamine

→

title compound

(2S, 4R)-1-(t-Butoxycarbonyl)-2-methylcarbamoyl-4-hydroxypyrrolidine

용매

tetrahydrofuran

triethylamine

tetrahydrofuran

반응 조건

후처리

1. 1
   기타to rise to room temperature
2. 2
   workup.WAITto continue for 1 hour
3. 3
   추출extracted thrice with ethyl acetate
4. 4
   세척The combined extracts were washed with an aqueous solution of sodium chloride
5. 5
   건조dried over anhydrous magnesium sulfate
6. 6
   기타The solvent was then removed by distillation under reduced pressure

실험 절차

9.91 ml of triethylamine were added at -40° C. to a solution of 15.03 g of (2S, 4R)-1-(t-butoxycarbonyl)-4-hydroxy-2-pyrrolidinecarboxylic acid dissolved in 250 ml of dry tetrahydrofuran, and then a solution of 6.81 ml of ethyl chloroformate in 30 ml of dry tetrahydrofuran was added at -30° to -40° C. to the resulting mixture, which was then stirred at the same temperature for 1 hour, 16.82 ml of a 40% by volume aqueous methylamine solution were then added at -30° C., and the temperature of the reaction mixture was allowed to rise to room temperature; the reaction was then allowed to continue for 1 hour. At the end of this time, the reaction mixture was mixed with a small amount of an aqueous solution of sodium chloride and extracted thrice with ethyl acetate. The combined extracts were washed with an aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate. The solvent was then removed by distillation under reduced pressure, giving 12.76 g of the title compound as a colorless oil.

출처